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Abstract #3688

CSF transport of 18F and 18FDG via the brain-wide glymphatic pathway visualized by Integrative PET-MRI

Helene Benveniste1, Hedok Lee1, Michael Budassi2, S. David Smith3, Mark Schweitzer4, Nora Volkow5, Maiken Nedergaard6, and Paul Vaska4

1Anesthesiology, Yale School of Medicine, New Haven, CT, United States, 2Biomedical Engineering, Stony Brook Medicine, Stony Brook, NY, United States, 3SAII, Stony Brook, NY, United States, 4Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 5NIAAA, Bethesda, MD, United States, 6University of Copenhagen, Copenhagen, Denmark

The glymphatic pathway was recently re-discovered as a CSF transport system for brain waste removal. The peri-vascular space functions as the ”front end” for toxic waste clearance via the ‘glymphatic pathway. To facilitate future translation to the clinic we executed experiments to map glymphatic transport in the live rodent brain using dynamic integrated MRI-PET imaging in combination with CSF administration of a paramagnetic contrast agent and two different 18F-labeled radioisotopes.

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