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Abstract #3687

Quantitative Imaging for Development of PET/MRI phantoms

Peder Eric Zufall Larson1, Misung Han1, Peng Cao1, Hongyu An2, Kathryn Fowler2, Kathryn Keenan3, Karl F. Stupic3, Richard Laforest2, and Thomas Hope1

1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, 2Radiology, Washington University, St. Louis, MO, United States, 3National Institute of Standards and Technology, Boulder, CO, United States

This project aims to develop PET/MR phantoms to evaluate MR-based attenuation correction (MRAC) methods and allow standardization of PET results across PET/MRI scanners. This will be accomplished using quantitative ultrashort echo-time (UTE) imaging methods for measurement of T1, T2* and proton density of in vivo tissue types and candidate phantom materials, along with CT measurements of attenuation coefficients. UTE methods are required to characterize bone and choose bone mimics, as this is the most challenging tissue type for MRAC methods to capture.

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