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Abstract #3694

Gadolinium complexes conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs) as potential inflammation targeting MRI contrast agents.

Heekyung Kim1,2, Bokyung Sung3, Soyeon Kim3, Garam Choi3, Ah Rum Baek3, Md Kamrul Islam3, Taekwan Lee4, DongKyu Kim4, Hoe Su Jung4, and Yongmin Chang2,3,5

1Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Republic of Korea, 2Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Republic of Korea, 3Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea, 4Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea, 5Department of Radiology, Kyungpook National University, Daegu, Republic of Korea

Inflammation targeting MR CAs conjugated with NSAIDs were prepared according to the general synthetic methods, and characterized by spectroscopic analysis. The relaxivities of theses gadolinium complexes are slightly higher than those of Gadovist®. From in vivo T1-weighted MR images, strong enhancement was observed in the inflammatory region. Also our new gadolinium complexes represent high kinetic inertness in chemically competitive environment compared with other clinically used MR CAs.

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