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Abstract #3695

Small CaF2 nanocrystals as nano-sized tracers for in vivo 19F-MRI

Idan Ashur1, Hyla Allouche-Arnon1, and Amnon Bar-Shir1

1Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel

In this study we present a novel class of 19F-nanoformulations based on small (<10 nm) fluoride-nanocrystals (specifically CaF2 nanofluorides) for MRI applications. We show that homonuclear dipolar interactions can be averaged out by the fast tumbling of the PEG-coated nanocrystals thus enabling the acquisition of high-resolution 19F-NMR. Using this feature, we demonstrate that our newly developed nanofluorides could be used as 19F-MRI tracers and present a “hot-spot” mapping in an animal model inflammation. The proposed nanofluorides combine the advantages of using nanocrystals (small, high 19F-equivalency, maximal 19F-density, and surface modifiability) with the merits of 19F-MRI tracers.

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