In this study we present a novel class of 19F-nanoformulations
based on small (<10 nm) fluoride-nanocrystals (specifically CaF2 nanofluorides)
for MRI applications. We show that homonuclear dipolar interactions can be averaged
out by the fast tumbling of the PEG-coated nanocrystals thus enabling the
acquisition of high-resolution 19F-NMR. Using this feature, we
demonstrate that our newly developed nanofluorides could be used as 19F-MRI
tracers and present a “hot-spot” mapping in an animal model inflammation. The
proposed nanofluorides combine the advantages of using nanocrystals (small,
high 19F-equivalency, maximal 19F-density, and surface
modifiability) with the merits of 19F-MRI tracers.
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