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Abstract #3696

Fluorine labeling and imaging of biomaterial scaffolds for regenerative medicine

Marcin Piejko1,2, Piotr Walczak1,3, Xiaowei Li4, Jeff W.M. Bulte1, and Miroslaw Janowski1,5

1Radiology, Johns Hopkins University, Baltimore, MD, United States, 23rd Department of General Surgery, Jagiellonian University, Cracow, Poland, 3Neurology and Neurosurgery, University of Warmia and Mazury, Olsztyn, Poland, 4Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, United States, 5Mossakowski Medical Research Centre, Warsaw, Poland

There is growing interest in stem cell-based regenerative medicine. Hydrogels can serve as injectable scaffolds for transplanted stem cells in order to provide mechanical support, as well as to mimic natural 3D tissue composition, while allowing for minimally invasive needle- or catheter-based delivery. However, the precision of hydrogel injections, as well as monitoring of gel biodegradation, remains challenging. We have shown that clinical grade fluorine nanoemulsion effectively and firmly labels hyaluronian-based hydrogel, supports survival of embedded stem cells, while only mildly changing rheological properties. Additionally, 19F MRI is very attractive as it does not interfere with anatomical and functional MRI.

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