Abstract #3697

Toward investigating cerebral metabolism using hyperpolarized pyruvate on a human 7T system

Sergey Cheshkov^1,2, Edward Hackett¹, Richard Martin¹, Sandeep Ganji^1,3, Ivan Dimitrov^1,3, and Jae Mo Park^1,2,4

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Philips Healthcare, Dallas, TX, United States, ⁴Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States

Advances in hyperpolarized MR technology and pre-clinical investigations have recently led to translational studies using clinical 3T human systems. While hyperpolarization provides large increase in MR sensitivity, spectral dispersion at 3T is limited which makes assessment of various metabolic pathways difficult. This work demonstrates the feasibility of using hyperpolarized ¹³C-pyruvate to study brain metabolism in a whole-body human 7T system. In particular, the benefit of increased chemical shift dispersion and ¹H-decoupling were tested in phantom and rat brains in vivo using hyperpolarized [1-¹³C]- and [2-¹³C]-labeled pyruvate. Longitudinal relaxation times of these hyperpolarized substrates at 7T are also reported.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.