Abstract #3698

Integrated B1+ Mapping for Hyperpolarized 13C MRI in a Clinical Setup using Multi-Channel Receive Arrays

Rie B Hansen¹, Peter J Shin², Jeremy W Gordon², Mark Van Criekinge², Lucas Carvajal², Lars G Hanson¹, Jan H Ardenkjær-Larsen¹, and Daniel B Vigneron²

¹Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ²Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

For hyperpolarized ¹³C MRI acquisitions aimed at metabolic rate constant estimation, the Bloch-Siegert shift enables encoding of the transmit field (B₁⁺-field) amplitude within a single hyperpolarized substrate injection. This ability is needed since most clinical hyperpolarized MRI studies use inhomogeneous transmit coils, and because kinetic modeling based on incorrect flip angles can lead to incorrect rate constant estimations. This study demonstrates the feasibility of integrated B₁⁺ mapping for large volume thermal and hyperpolarized phantoms in a clinical setup using a clamshell transmit coil and a 16-channel receive array, and a 3D stack-of-spirals sequence. Phase-sensitive coil-combination was achieved using ESPIRiT.

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