Abstract #3699

Hyperpolarized [1-13C]pyruvate MRS detects dynamic glucose metabolism according to stages of diabetes in mouse model

Young-suk Choi¹, Somang Kang², Hansol Lee³, Jae Eun Song³, Dong-Hyun Kim³, Jong Eun Lee², and Ho-Taek Song¹

¹Yonsei University College of Medicine, Seoul, Republic of Korea, ²Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea, ³Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea

Recently, diabetes has been suggested as a risk factor for inducing cognitive impairment. Thus, a quantitative imaging method to validate the metabolic status of the brain according to the stages of diabetes may help elucidate the relationship between the development of cognitive impairment and glucose metabolism of the brain. This study performed hyperpolarized [1-13C]pyruvate imaging in the brain of both pre-diabetes (Pre-DM) and type 2 diabetes (T2DM) mouse model. It shows dynamic brain glucose metabolism according to the stages of diabetes with excellent sensitivity.

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