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Abstract #3703

Noninvasive assessment of treatment response to histone deacetylase inhibitor and radiation for pediatric diffuse midline glioma using hyperpolarized carbon-13 metabolic imaging

Ilwoo Park1, Adam Autry2, Xiaodong Yang3, Yuying Zhai3, Renuka Sriram2, Dave Korenchan2, John Kurhanewicz2, Adam Cunha4, I-Chow Hsu4, and Sabine Mueller5

1Radiology, Chonnam National University, Gwangju, Republic of Korea, 2Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 3Neurology, University of California San Francisco, San Francisco, CA, United States, 4Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 5Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, United States

Diffuse midline glioma is one of the most difficult pediatric cancers to treat. This study investigated the feasibility of 13C magnetic resonance metabolic imaging of hyperpolarized [1-13C]pyruvate for monitoring response to novel therapies in diffuse midline glioma. Treatment with panobinostat was associated with a reduction in hyperpolarized lactate and a reduced LDHA activity in an in vitro experiment. Radiotherapy led to a reduction in the ratio of lactate to pyruvate in rats bearing diffuse midline glioma. The results suggest that hyperpolarized 13C metabolic imaging may provide an early noninvasive biomarker to monitor therapy response in diffuse midline glioma.

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