Abstract #3702

Correlation Between Hyperpolarized 13C-signal and Lactate Concentration in a Human Breast Cancer Xenograft Model

Casey Y. Lee^1,2, Benjamin J. Geraghty^1,2, Justin Y. C. Lau^1,2,3, Albert P. Chen⁴, Yi-Ping Gu², and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴GE Healthcare, Toronto, ON, Canada

Hyperpolarized ¹³C MRI has enabled metabolic (lactate- and pyruvate-) imaging in various clinical and pre-clinical studies to probe the production of lactate in tumours. A number of biological factors has been proposed to influence ¹³C-signal, with the total lactate pool size thought to be the dominant contributor based on the in vitro cell study by Day et al. In this study, we investigate whether the same relationship holds in a human breast cancer xenograft model in rats, as well as assessing the contributions from other biological components, including the rate of perfusion, transporters, and enzymes.

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