Abstract #3702

Correlation Between Hyperpolarized 13C-signal and Lactate Concentration in a Human Breast Cancer Xenograft Model

Casey Y. Lee^1,2, Benjamin J. Geraghty^1,2, Justin Y. C. Lau^1,2,3, Albert P. Chen⁴, Yi-Ping Gu², and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴GE Healthcare, Toronto, ON, Canada

Hyperpolarized ¹³C MRI has enabled metabolic (lactate- and pyruvate-) imaging in various clinical and pre-clinical studies to probe the production of lactate in tumours. A number of biological factors has been proposed to influence ¹³C-signal, with the total lactate pool size thought to be the dominant contributor based on the in vitro cell study by Day et al. In this study, we investigate whether the same relationship holds in a human breast cancer xenograft model in rats, as well as assessing the contributions from other biological components, including the rate of perfusion, transporters, and enzymes.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.