Meeting Banner
Abstract #3702

Correlation Between Hyperpolarized 13C-signal and Lactate Concentration in a Human Breast Cancer Xenograft Model

Casey Y. Lee1,2, Benjamin J. Geraghty1,2, Justin Y. C. Lau1,2,3, Albert P. Chen4, Yi-Ping Gu2, and Charles H. Cunningham1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 4GE Healthcare, Toronto, ON, Canada

Hyperpolarized 13C MRI has enabled metabolic (lactate- and pyruvate-) imaging in various clinical and pre-clinical studies to probe the production of lactate in tumours. A number of biological factors has been proposed to influence 13C-signal, with the total lactate pool size thought to be the dominant contributor based on the in vitro cell study by Day et al. In this study, we investigate whether the same relationship holds in a human breast cancer xenograft model in rats, as well as assessing the contributions from other biological components, including the rate of perfusion, transporters, and enzymes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here