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Abstract #3707

Imaging Regional Distribution of Metabolic Activity During Progression of Acute Lung Injury using Hyperpolarized Carbon-13 MRI

Mehrdad Pourfathi1, Maurizio Cereda2, Shampa Chatterjee3, Yi Xin1, Stephen Kadlecek1, Hooman Hamedani1, Ian Duncan1, Sarmad Siddiqui1, Harrilla Profka1, Kai Ruppert1, Luis Loza1, Faraz Amzajerdian1, Ryan Baron1, Mary Spencer1, Tahmina Achekzai1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 3Physiology, University of Pennsylvania, Philadelphia, PA, United States

We used hyperpolarized [1-13C] pyruvate MRI to assess regional alterations in lactate production during progression of acute lung injury. While the average lactate-to-pyruvate ratio and its standard deviation increased globally in lungs ventilated without recruitment, the average ratio increased more significantly in the posterior regions than the average ratio in the anterior region. The average lactate-to-pyruvate remained unchanged in lungs ventilated with recruitment maneuver. Our finding suggests that stretch-induced atelectasis and inflammation are the root of increased lactate-to-pyruvate ratio in the lungs ventilated without recruitment.

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