Abstract #3707

Imaging Regional Distribution of Metabolic Activity During Progression of Acute Lung Injury using Hyperpolarized Carbon-13 MRI

Mehrdad Pourfathi¹, Maurizio Cereda², Shampa Chatterjee³, Yi Xin¹, Stephen Kadlecek¹, Hooman Hamedani¹, Ian Duncan¹, Sarmad Siddiqui¹, Harrilla Profka¹, Kai Ruppert¹, Luis Loza¹, Faraz Amzajerdian¹, Ryan Baron¹, Mary Spencer¹, Tahmina Achekzai¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, ³Physiology, University of Pennsylvania, Philadelphia, PA, United States

We used hyperpolarized [1-¹³C] pyruvate MRI to assess regional alterations in lactate production during progression of acute lung injury. While the average lactate-to-pyruvate ratio and its standard deviation increased globally in lungs ventilated without recruitment, the average ratio increased more significantly in the posterior regions than the average ratio in the anterior region. The average lactate-to-pyruvate remained unchanged in lungs ventilated with recruitment maneuver. Our finding suggests that stretch-induced atelectasis and inflammation are the root of increased lactate-to-pyruvate ratio in the lungs ventilated without recruitment.

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