Abstract #3708

Evaluating hyperpolarized lactate as a theranostic agent for stroke

Jean-Noël Hyacinthe^1,2, Lara Buscemi³, Mario Lepore⁴, Rolf Gruetter^4,5,6,7, Lorenz Hirt³, and Mor Mishkovsky⁵

¹School of Health Sciences - Geneva, University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, ²Image Guided Intervention Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland, ³Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, ⁴Centre d'Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁶Department of Radiology, University of Geneva, Geneva, Switzerland, ⁷Department of Radiology, University of Lausanne, Lausanne, Switzerland

Stroke is the leading cause of disability and the third leading cause of death worldwide. Lactate administration into the ischemic brain directly after blood reperfusion was found to be neuroprotective. MR with hyperpolarized (HP) probes enables in vivo real-time measurement of biochemical transformations of HP ¹³C-labeled precursors, including lactate. The aim of this study was to demonstrate the feasibility of probing HP [1-¹³C]L-lactate metabolism in mice brain after ischemic stroke, and to study the influence of the time window after reperfusion on its conversion in order to evaluate the potential of HP lactate as a theranostic agent for stroke.

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