Hyperpolarized MRI was employed to non-invasively assess aerobic glycolysis in a well-characterized, patient-derived, orthotopic glioblastoma mouse model which recapitulates the complexity of tumor microenvironment. Aberrant energy metabolism is a hallmark of cancer, and in order to understand this metabolic rewiring during the course of tumor development, in vivo hyperpolarized pyruvate metabolic imaging and NMR spectroscopy of ex vivo tumor tissue were performed at three separate time points. A positive correlation of dynamic lactate production with tumor progression was observed. Additionally, NMR metabolomics revealed several key metabolites that are positively or negatively correlated with tumor growth.
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