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Abstract #3713

Detection of Targeted Therapy Treatment Response using Hyperpolarized Magnetic Resonance Spectroscopy in Breast Cancer Cell Lines

Sui Seng Tee1, Kristin L Granlund1, Roozbeh Eskandari1, Sangmoo Jeong1, Steven Truong1, and Kayvan Rahimi Keshari1

1Memorial Sloan Kettering Cancer Center, New York, NY, United States

Hyperpolarized magnetic resonance spectroscopy (HP-MRS) allows non-invasive real-time monitoring of cancer metabolism. This unique ability allows investigation of changes in cancer metabolism after therapy. This study demonstrates the utility of this modality to detect lowered conversion of hyperpolarized pyruvate to lactate after targeted therapy against a commonly mutated growth signaling pathway in cancer. We also demonstrate changes in enzyme phosphorylation that may explain changes in HP-MRS.

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