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Abstract #3714

HP [1-13C] Pyruvate-derived metabolic biomarkers are an early predictor of lung rejection in the rat lung transplantation model

Sarmad Siddiqui1, Mehrdad Pourfathi1, Andreas Habertheuer2, Yi Xin1, Hooman Hamedani1, Prashanth Vallabhajosyula2, Ali Naji2, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2University of Pennsylvania, Philadelphia, PA, United States

Post-transplant lungs are clinically monitored using regular radiography and/or CT scans to detect rejection. We proposed that a metabolic biomarker may provide higher sensitivity than conventional tools at the onset of rejection, before permanent structural changes in the lungs. Using HP [1-13C] pyruvate CSI, we found that the HP lactate-to-pyruvate ratio in the transplanted lung was significantly elevated in the rejected cohort (~1.7-fold on day 3, ~2.7-fold on day 7) compared to the non-rejected cohort and can be potentionally used as an early predictor of lung rejection.

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