Abstract #3743

The Abnormal Cerebral Perfusion Profile in older adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin Labelling MRI

Sara Marie Dupont¹, David McCoy¹, Andrew Callen¹, Duygu Tosun¹, Joanna Hellmuth², Victor Valcour^2,3, and Jared Narvid¹

¹Department of Radiology and Biomedical Imaging, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States, ²Department of Neurology, University of California San Francisco, San Francisco, CA, United States, ³Division of Geriatric Medicine, University of California San Francisco, San Francisco, CA, United States

This study aimed at evaluating the pattern of cerebral blood flow (CBF) abnormalities in older adults with HIV-associated neurocognitive disorder (HAND) compared to cognitively healthy controls. Pulsed ASL (for CBF quantification) and T1-weighted images (for registration to cortical parcellation atlas) were collected in a retrospective cohort of 19 HIV+ participants and 15 age and education matched controls. To investigate differences in CBF patterns between HIV+ and controls, CBF values were used to train generalized linear models (GLMnet) to predict patient diagnosis. Older HIV+ exhibited lower CBF values in the temporal and occipital lobes compared to controls suggesting a specific pattern of CBF in individuals aging with HAND.

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