To evaluate the characteristics of chemical exchange proton pools using a CEST MRI technique in dementia patients, 19 demented and 22 non-demented subjects were scanned a full Z spectrum data using a 3D GRASE sequence. The 6 pool maps with the Lorentzian fitting and MTR asymmetry map pool were calculated and compared between the two groups. The amide, amine, hydroxyl, DWS, NOE, MT, and MTR asymmetry values at 1 ppm, 3ppm, and 3.5 ppm were higher in the demented group than in the non-demented group.
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