Abstract #3747

Assessment of different molecular iron forms in the brain tissue of Alzheimer patients

Lucia Bossoni^1,2, Marjolein Bulk¹, Wico H. Breimer², Andrew G. Webb¹, Jelle Goeman³, Martina Huber², Tjerk H. Oosterkamp², and Louise van der Weerd^1,4

¹Radiology Dept., Leiden University Medical Center, Leiden, Netherlands, ²Leiden Institute of Physics, Leiden, Netherlands, ³Biostatistics Dept., Leiden University Medical Center, Leiden, Netherlands, ⁴Human Genetics Dept., Leiden University Medical Center, Leiden, Netherlands

Magnetic Resonance Imaging (MRI) has the potential to measure iron accumulation in the brain of Alzheimer patients. However, current MRI techniques cannot differentiate between different molecular iron forms. We have recently developed a combination of MRI, EPR and SQUID magnetometry, to quantify specific molecular iron forms in brain tissue. In this current study of AD patients and controls we found significant differences in R₂^*, ferritin concentration, and magnetic moment of magnetite nanoparticles between patients (N=22) and controls (N=14). Additionally, we identified correlations between some iron forms.

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