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Abstract #3748

Oxygen extraction fraction is differentially affected in aging and Alzheimer’s disease: cross-sectional and longitudinal investigations in mice at 11.7T

Zhiliang Wei1,2, Lin Chen1,2,3, Zixuan Lin4, Jiadi Xu1,2, Siyuan Cheng5, Zheyu Wang5, Peter van Zijl1,2, and Hanzhang Lu1,2,4

1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Electronic Science, Xiamen University, Baltimore, MD, United States, 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 5Division of Biostatistics & Bioinformatics, Johns Hopkins University, Baltimore, MD, United States

Quantification of oxygen extraction fraction (OEF) is traditionally challenging and often requires the use of radiotracers or other invasive procedures, but has become feasible with recent advances in MR oximetry techniques. Here, we investigated the OEF in aging and Alzheimer’s disease (AD) with the T2-Relaxation-Under-Spin-Tagging (TRUST) technique. Based on the cross-sectional and longitudinal investigations, we demonstrated that normal aging and AD have different effects on brain OEF, which may reflect the dynamic nature of changes in brain energy homeostasis during these two processes. TRUST MRI may be a useful tool in elucidating physiological mechanisms of brain diseases in mouse models.

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