Abstract #3748

Oxygen extraction fraction is differentially affected in aging and Alzheimer’s disease: cross-sectional and longitudinal investigations in mice at 11.7T

Zhiliang Wei^1,2, Lin Chen^1,2,3, Zixuan Lin⁴, Jiadi Xu^1,2, Siyuan Cheng⁵, Zheyu Wang⁵, Peter van Zijl^1,2, and Hanzhang Lu^1,2,4

¹Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Electronic Science, Xiamen University, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁵Division of Biostatistics & Bioinformatics, Johns Hopkins University, Baltimore, MD, United States

Quantification of oxygen extraction fraction (OEF) is traditionally challenging and often requires the use of radiotracers or other invasive procedures, but has become feasible with recent advances in MR oximetry techniques. Here, we investigated the OEF in aging and Alzheimer’s disease (AD) with the T2-Relaxation-Under-Spin-Tagging (TRUST) technique. Based on the cross-sectional and longitudinal investigations, we demonstrated that normal aging and AD have different effects on brain OEF, which may reflect the dynamic nature of changes in brain energy homeostasis during these two processes. TRUST MRI may be a useful tool in elucidating physiological mechanisms of brain diseases in mouse models.

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