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Abstract #3750

In-vivo mapping of monoaminergic network disruption in Alzheimer’s disease: implications for neuropsychiatric symptoms

Laura Serra1, Marcello D'Amelio2, Carlotta Di Domenico1, Camillo Marra3, Nicola Biagio Mercuri4, Carlo Caltagirone5, Mara Cercignani1,6, and Marco Bozzali1,6

1Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy, 2Laboratory Molecular Neurosciences, Santa Lucia Foundation IRCSS, Rome, Italy, 3Institute of Neurology, Catholic University, Rome, Italy, 4Laboratory of Experimental Neurology, Santa Lucia Foundation IRCCS, Rome, Italy, 5Department of Clinical and Behavioural Neurology, Santa Lucia Foundation IRCCS, Rome, Italy, 6Department of Neuroscience, Brighton & Sussex Medical School, Brighton, United Kingdom

Some recent animal models and neuropathological evidence highlighted the loss of noradrenergic neurons in the locus coeruleus and dopaminergic neurons in the ventral tegmental area (VTA) as important pathophysiological events in Alzheimer's disease. Here we use resting-state functional MRI to show reductions in VTA connectivity in patients with Alzheimer's disease and mild cognitive impairment, which are more prominent in patients with neuropsychiatric symptoms.

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