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Abstract #3751

Loss of Intra- and Inter-Network Resting State Functional Connectivity in Patients with Mild and Moderate Alzheimer’s Disease

Yiqiu Liu1, Man Sun2, Yuanyuan Chen3, Xiuwei Fu1, Tianyi Qian4, and Hongyan Ni5

1Department of Radiology, First Central College,Tianjin medical university, Tianjin, China, 2Department of Radiology, Tianjin Hospital, Tianjin, China, 3Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China, 4MR Collaboration NEA, Siemens Healthcare, Beijing, China, 5Department of Radiology, Tianjin first center hospital, Tianjin, China

This study aimed to investigate the differences in the alteration of the entire brain network functional connectivity of mild and moderate AD patients based on fMRI, taking the cerebellum network into consideration. There have seldom been reports regarding the cerebellum and cerebral connectivity alteration during the progression of clinical AD. Moreover, the cerebellum network functional connectivity is significantly changed in moderate AD, and we further suspected that the cerebellum network is a pivotal one in the progression to the moderate AD stage.

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