Abstract #3751

Loss of Intra- and Inter-Network Resting State Functional Connectivity in Patients with Mild and Moderate Alzheimer’s Disease

Yiqiu Liu¹, Man Sun², Yuanyuan Chen³, Xiuwei Fu¹, Tianyi Qian⁴, and Hongyan Ni⁵

¹Department of Radiology, First Central College,Tianjin medical university, Tianjin, China, ²Department of Radiology, Tianjin Hospital, Tianjin, China, ³Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China, ⁴MR Collaboration NEA, Siemens Healthcare, Beijing, China, ⁵Department of Radiology, Tianjin first center hospital, Tianjin, China

This study aimed to investigate the differences in the alteration of the entire brain network functional connectivity of mild and moderate AD patients based on fMRI, taking the cerebellum network into consideration. There have seldom been reports regarding the cerebellum and cerebral connectivity alteration during the progression of clinical AD. Moreover, the cerebellum network functional connectivity is significantly changed in moderate AD, and we further suspected that the cerebellum network is a pivotal one in the progression to the moderate AD stage.

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