The aim of this study was to measure the difference in cortical thickness, subcortical volume and CSF biomarkers between MCI patients who carry or lack ApoE ε4 allele. High-resolution T1-weighted images were used for the measurement of cortical thickness and subcortical volume using FreeSurfer. MCI patients who carry ApoE ε4 showed significant reduction in cortical thickness and subcortical volume in multiple brain regions than non-carriers. This suggests that having an ApoE ε4 allele could be a risk factor for the larger tissue damage in the brain of MCI, and these patients may have higher chance of developing Alzheimer’s or other dementia.
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