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Abstract #3754

Semiautomatic Quantification of Cortical Amyloid with 18F-florbetaben PET/MRI in Alzheimer's disease and Other Neurodegenerative Disorders

JeeYoung Kim1,2, Audrey P. Fan2, Fabiola Bezerra de Carvlho Macruz2, Jia Guo2, Athanasia Boumis3, Michael Greicius3, Sharon Sha3, Minal Vasanawala2, Michael Moseley2, Michael Zeineh2, and Greg Zaharchuk2

1Radiology, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea, 2Radiology, Stanford University, Stanford, CA, United States, 3Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States

Amyloid PET is a useful quantitative biomaker in patients with dementia. We compared cortical amyloid deposition in Alzheimer’s disease (AD), Parkinson’s disease (PD), mild cognitive impairment (MCI) and cognitively normal elderly subjects and correlated it with cortical CBF and volume using simultaneous 18F-florbetaben PET/MRI. Total cortical SUV is significantly higher in AD than PD and MCI. Precuneus, superior temporal, and calcarine cortices were identified as significant regions on amyloid PET to discriminate between AD and other neurodegenerative diseases.

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