Abstract #3754

Semiautomatic Quantification of Cortical Amyloid with 18F-florbetaben PET/MRI in Alzheimer's disease and Other Neurodegenerative Disorders

JeeYoung Kim^1,2, Audrey P. Fan², Fabiola Bezerra de Carvlho Macruz², Jia Guo², Athanasia Boumis³, Michael Greicius³, Sharon Sha³, Minal Vasanawala², Michael Moseley², Michael Zeineh², and Greg Zaharchuk²

¹Radiology, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea, ²Radiology, Stanford University, Stanford, CA, United States, ³Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States

Amyloid PET is a useful quantitative biomaker in patients with dementia. We compared cortical amyloid deposition in Alzheimer’s disease (AD), Parkinson’s disease (PD), mild cognitive impairment (MCI) and cognitively normal elderly subjects and correlated it with cortical CBF and volume using simultaneous 18F-florbetaben PET/MRI. Total cortical SUV is significantly higher in AD than PD and MCI. Precuneus, superior temporal, and calcarine cortices were identified as significant regions on amyloid PET to discriminate between AD and other neurodegenerative diseases.

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