Binswanger's disease (BD) is a form of vascular dementia which is prevalent in older population. BD is characterized by the presence of white matter lesions due to injured small vessels in the brain. Magnetic resonance imaging findings related to BD reported large white matter lesions in FLAIR and high blood-brain barrier permeability in dynamic contrast enhanced MRI. Changes in water diffusion in white matter lesions and axonal damage were reported using diffusion tensor imaging metrics. While all the studies focused on exploring the voxel level measures as BD markers, we aimed to quantify the WM integrity through measures estimated for fibers within a voxel. In this study, we apply fixel-based analysis (FBA) to multi-shell diffusion data to evaluate the fiber specific measures such as fiber density (FD) and fiber cross-section (FC) in regions of white matter lesions in BD subjects and compared the measures with healthy controls. Reduced FD and FDC are revealed in areas of white matter lesions in BD subjects as compared to those in control group.
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