Abstract #3765

The Application of NODDI in Characterizing Brain Microstructural Changes in Type 2 Diabetes with Cognitive Impairment

Ying Xiong¹, Qiang Zhang², Yang Fan³, and Wenzhen Zhu¹

¹Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³GE Healthcare, Beijing, China

This study aims to investigate brain microstructural changes in white-matter and gray-matter of type 2 diabetes mellitus(T2DM) patients using the NODDI model. Thirty-three T2DM patients were divided into two sub-groups (impaired and normal cognition), together with ten healthy controls, were imaged at a 3T scanner. It was found that the T2DM patients with cognitive impairment had a lower ICVF value compared to healthy controls in WM regions and the thalamus. Decreased ICVF values in the genu of corpus callosum were correlated with HbA1c level. The NODDI model shows potential feasibility in characterizing brain microstructural alterations for patients with T2DM.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.