The aim of this study was to investigate whether the volumes of subcortical gray matter structures in alcohol-dependent patients (ADP) are different, and to localize the surface morphometric changes of these subcortical structures. Compared with healthy controls (HC), we found that the bilateral Accu, Hipp, Puta, and Thal showed significant atrophy in ADP. We also revealed that vertex analysis directly can measure localized changes in brain structures that showed significant volumetric change. It might have potential to precisely detect regional alterations of the subcortical gray matter structures.
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