Abstract #3768

MR Spectroscopy Biomarker Discovery Algorithms (MBDA) to Discriminate PTSD from Blast Exposure and Healthy Controls

Nathan Tosh^1,2, Laura Mariano³, Scott Quadrelli⁴, Graham Galloway^1,2, Valerie Graves¹, Aaron Urquhart¹, Peter Malycha^1,2, Katie Trickey¹, Lisa Rich¹, Rosanna Tremewan¹, John Irvine³, and Carolyn Mountford¹

¹Translational Research Institute, Brisbane, Australia, ²Queensland University of Technology, Brisbane, Australia, ³Draper, Boston, MA, United States, ⁴University of Newcastle, Newcastle, Australia

Single Voxel Point RESolved Spectroscopy (PRESS) was used to obtain neuro-metabolite and lipid levels from the Posterior Cingulate Gyrus (PCG) of 4 cohorts – Control, Civilian PTSD, Artillery and Close Combat soldiers. Using a wavelet based statistical analysis approach classifiers were developed to objectively diagnose and monitor neuro-deregulation associated with PTSD and blast injury to artillery and to close combat soldiers.

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