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Abstract #3769

ADHD and stimulant medication disrupt the temporal lag structure within default mode and salience networks

Charlotte Clarke1, Arjun Sethi1,2, Mara Cercignani1, and Neil Harrison1

1Department of Neuroscience, Brighton and Sussex Medical School, Falmer, United Kingdom, 2Clinical, Edu & Hlth Psychology, University College London, London, United Kingdom

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that has been associated with reduced Default Mode (DMN) (precuneus) and salience network (Anterior Cingulate) activity in conventional resting-state fMRI studies (rs-fMRI). However, these studies ignore the significant temporal structure in these data. Thirty ADHD patients and 30 matched controls underwent rs-fMRI on two occasions, 90-minutes after blindly administered stimulant medication and placebo. Using a novel ‘lag-thread’ analysis we demonstrate faster recruitment of the precuneus in ADHD which additionally correlated with severity of inattention. Stimulants slowed ACC recruitment, together suggesting potential importance of temporal activation of these regions in ADHD.

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