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Abstract #3770

BMI correlates with tissue stiffness in deep gray matter regions controlling eating behavior

Stefan Hetzer1,2, Martin Weygandt1,3, Sebastian Hirsch1,2, Jürgen Braun4, and Ingolf Sack5

1Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Bernstein Center for Computational Neuroscience, Berlin, Germany, 3Cluster of Excellence NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, 5Institute of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

Cerebral MR elastography was applied to a group of healthy male subjects in the normal weight range up to overweight to explore a potential relationship between the in vivo mechanical properties of brain tissue and body-mass index (BMI). We observed a highly significant negative correlation between tissue stiffness and BMI in the globus pallidus and putamen – two regions identified in the literature as being linked to eating behaviour – while the stiffness of other brain regions did not correlate with BMI. This is the first report on in vivo mechanical properties of brain tissue related to BMI.

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