Abstract #3770

BMI correlates with tissue stiffness in deep gray matter regions controlling eating behavior

Stefan Hetzer^1,2, Martin Weygandt^1,3, Sebastian Hirsch^1,2, Jürgen Braun⁴, and Ingolf Sack⁵

¹Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Bernstein Center for Computational Neuroscience, Berlin, Germany, ³Cluster of Excellence NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁵Institute of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

Cerebral MR elastography was applied to a group of healthy male subjects in the normal weight range up to overweight to explore a potential relationship between the in vivo mechanical properties of brain tissue and body-mass index (BMI). We observed a highly significant negative correlation between tissue stiffness and BMI in the globus pallidus and putamen – two regions identified in the literature as being linked to eating behaviour – while the stiffness of other brain regions did not correlate with BMI. This is the first report on in vivo mechanical properties of brain tissue related to BMI.

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