Abstract #3796

CT-based surrogates of ventilation: A comparison with hyperpolarized Helium-3 and Xenon-129 MRI in lung cancer patients undergoing radiotherapy planning

Bilal A. Tahir^1,2, Paul J. Hughes¹, Stephen D. Robinson^1,2, Helen Marshall¹, Alberto Biancardi¹, Neil J. Stewart¹, Graham Norquay¹, Ho-Fung Chan¹, Guilhem J. Collier¹, Kerry A. Hart², James A. Swinscoe², Matthew Q. Hatton², Jim M. Wild¹, and Rob H. Ireland²

¹Polaris, University of Sheffield, Sheffield, United Kingdom, ²Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom

Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung ‘ventilation’ and has notable applications in functionally guided radiotherapy planning. However, the technique requires validation against established ventilation modalities such as hyperpolarized gas MRI. Here, we develop an image acquisition and analysis strategy to facilitate direct spatial correlation of several CT ventilation techniques with both hyperpolarized ³He and ¹²⁹Xe MRI and apply our method to a cohort of 11 lung cancer patients undergoing radiotherapy.

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