Abstract #3797

Evaluation of MRI-Guided Radiotherapy Planning Target Volume Delineation for Colorectal Cancer Due to Variations in Image Contrast and Patient Motion

Yang Zhang¹, Liming Shi², Xiaonan Sun², Tianye Niu², Ning Yue³, Jeon-Hor Chen¹, Tiffany Kwong^1,3, Min-Ying Su¹, and Ke Nie³

¹Department of Radiological Sciences, University of California, Irvine, CA, United States, ²Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, ³Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, United States

This study evaluates the difference in defining the target volume of rectal cancer with MRI-guided radiation treatment planning. Tumors show different appearances on different MR sequences, and also the motion of patients during the scan may affect defining planning target volume. A quantitative radial distance method was developed to evaluate variations coming from image contrast and patient motion. A total of 45 patients with pre- and post-radiation treatment MRI were analyzed. The mean difference in the radial distance between ROI’s drawn on different post-contrast images was 2-3 mm, and the difference in the 90th percentile tumor pixel was 6-8 mm.

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