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Abstract #3797

Evaluation of MRI-Guided Radiotherapy Planning Target Volume Delineation for Colorectal Cancer Due to Variations in Image Contrast and Patient Motion

Yang Zhang1, Liming Shi2, Xiaonan Sun2, Tianye Niu2, Ning Yue3, Jeon-Hor Chen1, Tiffany Kwong1,3, Min-Ying Su1, and Ke Nie3

1Department of Radiological Sciences, University of California, Irvine, CA, United States, 2Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, 3Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, United States

This study evaluates the difference in defining the target volume of rectal cancer with MRI-guided radiation treatment planning. Tumors show different appearances on different MR sequences, and also the motion of patients during the scan may affect defining planning target volume. A quantitative radial distance method was developed to evaluate variations coming from image contrast and patient motion. A total of 45 patients with pre- and post-radiation treatment MRI were analyzed. The mean difference in the radial distance between ROI’s drawn on different post-contrast images was 2-3 mm, and the difference in the 90th percentile tumor pixel was 6-8 mm.

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