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Abstract #3818

Intravoxel incoherent motion (IVIM) provides reliable measures of blood volume in patients with metastases to the brain

Line Brennhaug Nilsen1, Knut Håkon Hole2, Ingrid Digernes1, Endre Grøvik3, Oliver Geier1, Edmund Reitan2, Cathrine Saxhaug4, Åslaug Helland4, Kari Dolven Jacobsen4, Birger Breivik5, Dag Ottar Sætre6, and Kyrre Eeg Emblem1

1Diagnostic Physics, Oslo University Hospital, Oslo, Norway, 2Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 3Diagnostic Physic, Oslo University Hospital, Oslo, Norway, 4Oslo University Hospital, Oslo, Norway, 5Hospital of Southern Norway, Kristiansand, Norway, 6The Hospital Østfold Kalnes, Kalnes, Norway

In this study, we aimed to assess the potential of using intravoxel incoherent motion (IVIM) for measuring cerebral blood volume (CBV) in brain metastases and normal brain tissue. DWI was acquired with b=0, 200, 300 and 1000s/mm2 in nineteen patients with 23 brain metastases from lung cancer. Asymptotic IVIM fitting yielded an estimation of the perfusion fraction, and subsequent estimation of CBV. CBVDWI in brain metastases and gray matter correlated significantly with CBV obtained from conventional DSC MRI. Our results suggest that IVIM may serve as an independent and reliable surrogate marker of blood volume in well perfused brain tissue.

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