Abstract #3818

Intravoxel incoherent motion (IVIM) provides reliable measures of blood volume in patients with metastases to the brain

Line Brennhaug Nilsen¹, Knut Håkon Hole², Ingrid Digernes¹, Endre Grøvik³, Oliver Geier¹, Edmund Reitan², Cathrine Saxhaug⁴, Åslaug Helland⁴, Kari Dolven Jacobsen⁴, Birger Breivik⁵, Dag Ottar Sætre⁶, and Kyrre Eeg Emblem¹

¹Diagnostic Physics, Oslo University Hospital, Oslo, Norway, ²Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ³Diagnostic Physic, Oslo University Hospital, Oslo, Norway, ⁴Oslo University Hospital, Oslo, Norway, ⁵Hospital of Southern Norway, Kristiansand, Norway, ⁶The Hospital Østfold Kalnes, Kalnes, Norway

In this study, we aimed to assess the potential of using intravoxel incoherent motion (IVIM) for measuring cerebral blood volume (CBV) in brain metastases and normal brain tissue. DWI was acquired with b=0, 200, 300 and 1000s/mm² in nineteen patients with 23 brain metastases from lung cancer. Asymptotic IVIM fitting yielded an estimation of the perfusion fraction, and subsequent estimation of CBV. CBV_DWI in brain metastases and gray matter correlated significantly with CBV obtained from conventional DSC MRI. Our results suggest that IVIM may serve as an independent and reliable surrogate marker of blood volume in well perfused brain tissue.

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