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Abstract #3819

In Vivo Assessment of Lauren Classification for Gastric Cancer Using Diffusion MRI with a Fractional Order Calculus Model

Muge Karaman1, Lei Tang2, Ziyu Li3, Yu Sun4, Jia Fu Ji3, and Xiaohong Joe Zhou1,5

1Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, 2Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, China, 3Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing, China, 4Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China, 5Departments of Radiology, Neurosurgery, and Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Gastric cancer (GC) is the second most common cause of cancer-related mortality globally. Histological assessment of GC has been based on Lauren classification which categorizes the tumor according to its morphological features. In respond to the need for probing biological tissue complexity, a growing number of diffusion-weighted imaging studies have focused on revealing tissue microstructures by measuring non-Gaussian diffusion behaviors. One of these techniques is the fractional order calculus (FROC) model. In this study, we have used the FROC model to investigate non-invasive imaging-based assessment of GC, providing an alternative to histopathology-based Lauren classification.

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