Nodal disease on whole-body MRI (WB-MRI) is mainly assessed using size criteria that could misclassify sub-centimeter lymphomatous nodes. In this study we investigated the comparative performance of anatomical WB-MRI derived nodal-size and signal-intensity; and whole-body diffusion-weighted-imaging (WB-DWI) nodal-size and apparent-diffusion-coefficient (ADC) measurements for determination of nodal-disease status. We showed that diseased nodes had significantly lower ADCs than benign nodes. We also noticed that for nodes deemed negative for disease based on size criteria (measuring 5-9 mm) ADC was significantly lower for FDG PET-CT -positive compared to FDG PET-CT -negative nodes. We also note that the performance of ADC was not greater than simple size measurement and concluded that there were no added advantage for quantitative measurements to simple size criteria on WB-MRI.