Abstract #3821

Whole body 3.0 T MRI for Staging Lymphomas: An Assessment of Multiple Sequences Compared to Reference Standard Imaging

Arash Latifoltojar¹, Mark Duncan², Maria Klusmann², Alan Bainbridge³, Deena Neriman⁴, Francesco Fraioli⁴, Jonathan Lambert⁵, Kirit Ardeshna⁵, and Shonit Punwani¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Department of Radiology, University College London Hospital, London, United Kingdom, ³Department of Medical Physics and Biomedical Engineering, University College London Hospital, London, United Kingdom, ⁴Institute of Nucear Medicine, University College London Hospital, London, United Kingdom, ⁵Department of Haemato-oncology, University College London Hospital, London, United Kingdom

In lymphomas, whole-body MRI (WB-MRI), integrating structural / functional MRI sequences, offers an alternative radiation-free imaging method to standard radiological techniques. In this work, we evaluated multiple MRI sequences as part of a WB-MRI protocol for staging of 22 newly-diagnosed Hodgkin’s lymphoma and diffuse large B-cell lymphoma patients compared to reference-standard 18F-FDG PET-CT. We found that the performance of WB-MRI for nodal / extra-nodal disease detection and Ann-Arbor staging were at best when the entire protocol was reviewed. We observed an inferior diagnostic performance of WB-MRI using diffusion-weighted-imaging and an improved diagnostic performance when T2-weighted / post-contrast WB-MRI were reviewed.

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