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Abstract #3821

Whole body 3.0 T MRI for Staging Lymphomas: An Assessment of Multiple Sequences Compared to Reference Standard Imaging

Arash Latifoltojar1, Mark Duncan2, Maria Klusmann2, Alan Bainbridge3, Deena Neriman4, Francesco Fraioli4, Jonathan Lambert5, Kirit Ardeshna5, and Shonit Punwani1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Radiology, University College London Hospital, London, United Kingdom, 3Department of Medical Physics and Biomedical Engineering, University College London Hospital, London, United Kingdom, 4Institute of Nucear Medicine, University College London Hospital, London, United Kingdom, 5Department of Haemato-oncology, University College London Hospital, London, United Kingdom

In lymphomas, whole-body MRI (WB-MRI), integrating structural / functional MRI sequences, offers an alternative radiation-free imaging method to standard radiological techniques. In this work, we evaluated multiple MRI sequences as part of a WB-MRI protocol for staging of 22 newly-diagnosed Hodgkin’s lymphoma and diffuse large B-cell lymphoma patients compared to reference-standard 18F-FDG PET-CT. We found that the performance of WB-MRI for nodal / extra-nodal disease detection and Ann-Arbor staging were at best when the entire protocol was reviewed. We observed an inferior diagnostic performance of WB-MRI using diffusion-weighted-imaging and an improved diagnostic performance when T2-weighted / post-contrast WB-MRI were reviewed.

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