Abstract #3825

Diffusion weighted MRI simplifies therapy monitoring in TRAMP mice

Jana Kim¹, Caroline K Søgaard^2,3, Eugene Kim⁴, Tone F Bathen^1,5, Marit Otterlei^2,3, Siver A Moestue^1,6, and Deborah K Hill¹

¹Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, ²Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway, ³Clinic of Surgery, St. Olavs Hospital, Trondheim, Norway, ⁴Department of Neuroimaging, King's College London, London, United Kingdom, ⁵Department of Radiology, Department of Radiology, Trondheim, Norway, ⁶Department of Laboratory Medicine, Women’s and Children’s Health, Norwegian University of Science and Technology, Trondheim, Norway

Transgenic mouse models of prostate cancer have advantages over xenograft tumor models as the cancer arises spontaneously and can be studied in immunocompetent mice, thus being highly biologically relevant. However, in vivo monitoring of cancer progression and treatment response is challenging and most studies rely on prostate volume measurements. Here we show that diffusion weighted imaging is a helpful tool for assessing response to chemotherapy in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice.

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