Meeting Banner
Abstract #3832

Non-linear Mechanics Allows Non-invasive Quantification of Interstitial Fluid Pressure

Daniel Fovargue1, Jack Lee1, Marco Fiorito1, Adela Capilnasiu1, Sweta Sethi2, Stefan Hoelzl1, Jurgen Henk Runge1, Jose de Arcos1, Arnie Purushotham3, Khesthra Satchithananda3, David Nordsletten1, and Ralph Sinkus1

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Research Oncology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 3Division of Cancer Studies, King's College London, London, United Kingdom

Established tumour treatments include drugs and the emerging class of cell-based therapies. Individual tumours can counteract the delivery of the therapy, for example, they can feature high internal pressures (IFP) caused by blood vessels that are different from normal tissues. Furthermore, a drop in IFP is a well-established marker for successful therapy. Here we demonstrate in simulations, phantom experiments, fatty breast tissue, and a benign breast lesion that tissue biomechanics as quantified via MR-Elastography (MRE) allows in combination with non-linear mechanics to estimate IFP in absolute units non-invasively.

This abstract and the presentation materials are available to members only; a login is required.

Join Here