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Abstract #3833

Pilot Study of Rapid MR Pancreas Screening for Patients with BRCA Mutation

Giuseppe Corrias1, Andrea Agostini1, Gabriella Carollo2, Luca Saba3, and Lorenzo Mannelli1

1Radiology, MSKCC, New York, NY, United States, 2St. John's University, Jamaica, NY, United States, 3Radiology, Università degli studi di Cagliari, CAGLIARI, Italy

Patients with BRCA mutations are offered breast MRI because of their increased risk of breast cancer, but no screening strategy is available for other BRCA-associated malignancies including pancreatic ductal adenocarcinoma. In this protocol, we optimize the use of several recent developments in body MRI for a rapid pancreatic screening in BRCA mutation carriers: first, rapid relatively motion insensitive T2-weighted imaging (T2WI) and navigator triggering (NT), where real-time tracking of the diaphragm position is performed. Secondly advances in diffusion-weighted-imaging (DWI). These techniques have changed our ability to screen for malignancies, in specific organs, such as the pancreas.

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