Abstract #3834

Monitoring the Growth of Individual Tumours in the Mouse Lung using Cardio-Respiratory Synchronised bSSFP MRI

Ana L. Gomes¹, Paul Kinchesh¹, Danny Allen¹, Veerle Kersemans¹, Stuart Gilchrist¹, Luiza Madia-Lourenco², Anderson Ryan², and Sean C. Smart¹

¹CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ²Department of Oncology, University of Oxford, Oxford, United Kingdom

bSSFP imaging is used in-vivo to image small tumours in the mouse lung, at an isotropic resolution of 200µm in under 10 minutes per scan. Cardio-respiratory synchronisation using prospective gating control is used to minimise motion artefacts efficiently, and a 4 step RF phase cycle is used to eliminate banding artefact. Growth of individual tumours in multi-focal lung cancer can be measured with a throughput of >4 mice per hour.

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