Abstract #3848

Effect of the phase variation induced by eddy currents on localized spectroscopy fatty acid composition quantification and its correction

Angéline Nemeth¹, Benjamin Leporq¹, Amandine Coum^2,3, Giulio Gambarota^2,3, Kévin Seyssel⁴, Bérénice Segrestin⁵, Pierre-Jean Valette⁶, Martine Laville⁵, Olivier Beuf¹, and Hélène Ratiney¹

¹Univ. Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F69621, VILLEURBANNE, France, Lyon, France, ²INSERM, UMR 1099, Rennes, France, Rennes, France, ³Univ Rennes 1, LTSI, Rennes, France, Rennes, France, ⁴Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Lausanne, Switzerland, ⁵Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon, France, ⁶Hospices Civils de Lyon, Département d'imagerie digestive, CHU Edouard Herriot, Lyon, Lyon, France

Monte Carlo simulations and in vivo measurements on human abdominal adipose tissue were used to analyze the effect of the phase variation induced by eddy currents on localized spectroscopy fatty acid composition quantification (proportion of polyunsaturated, monounsaturated and saturated fatty acid). Monte Carlo simulations showed that base line distortions were able to strongly impact estimation of fatty acid composition. So we proposed a simple method to correct the base line using a second signal acquired with a longer TE. Test-retest variability of quantitative results was reduced using this correction.

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