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Abstract #3855

Intra- and inter-site reproducibility of single voxel MRS at 3T in the human brain

Carina Graf1,2, Erin L MacMillan3,4,5, Eric Fu6, Irene M Vavasour7, Trudy Harris7, Burkhard Mädler8, Anthony Traboulsee9, David KB Li7,9, Alex MacKay1,7, and Cornelia Laule1,2,7,10

1Department of Physics, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 3MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 4UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 5ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, 6Department of Statistics, University of British Columbia, Vancouver, BC, Canada, 7Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 8Philips Healthcare, Bonn, Germany, 9Division of Neurology, University of British Columbia, Vancouver, BC, Canada, 10Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

We investigated the intra- and inter-site reproducibility of 1H-MRS with short-TE PRESS at 3T acquired on a single manufacturer at 6 different sites. Metabolite concentrations were robust to small inconsistencies in voxel placement (mean alignment=86%), highlighting that site was not the driving factor for differences in metabolite concentrations. Between-subject differences drove the concentration variability for creatine, choline and myoinositol (42-65% of the variance). The mean intra-site coefficient of variation for the metabolites was between 2.5% and 5.3%. The results support the use of a large single voxel 1H-MRS acquisition from a single manufacturer for multi-site clinical trials.

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