Lactate is known as an end-product of aerobic glycolysis, and it has been considered as a potential biomarker of metabolic abnormalities occurred in different cerebral pathological states. However, the 1H MRS detection of lactate is hampered by the presence of co-resonant lipid and macromolecule resonances. The aim of this study was to evaluate the performance of different 1H MRS protocols applied in semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence, I) TE=16 ms, no inversion, II) TE=16 ms, TI= 300 ms, and III) TE=110 ms, no inversion in reliable detection of lactate in the brain using in vivo measurement and simulated spectra at different experimental condition. The in vivo measurement and simulation analysis suggests that short-TE 1H MRS approach without inversion pulse is likely to be a more reliable method for estimating the absolute concentration of lactate and other metabolites simultaneously from the human brain.
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