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Abstract #3858

Quantification and Assessment of T2 Relaxation Times of Human Bile Components with In Vivo MR Spectroscopy at 7T

Martin Gajdošík1,2, Marek Chmelík3,4,5, Emina Halilbasic6, Lorenz Pfleger2, Michael Trauner6, Siegfried Trattnig5,7, and Martin Krššák2,5,7

1Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York City, NY, United States, 2Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 3Faculty of Healthcare, University of Prešov, Prešov, Slovakia, 4Department of Radiology, General Hospital of Levoča, Levoča, Slovakia, 5High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 6Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 7Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

In vivo measurements of concentrations of bile components are of high interest for understanding and diagnosis of cholestatic diseases. We measured human bile in the gallbladder in vivo using single-voxel 1H-MR spectroscopy at 7T and assessed T2 relaxation times of water and eight bile components in healthy volunteers. With precise T2 correction, all eight bile components could be quantified with ultra-short TE sequence and four with long TE sequence.

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