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Abstract #3859

A 3 Minute Clinical Protocol for Quantitative High-Speed MR Spectroscopic Imaging in Patients with Brain Tumors

Troy Hutchins-Delgado1, Mohammad Omar Chohan2, Kevin Tagne Fotso1, Lakshmisree Damodaran1, Howard Yonas2, Mona D Chaney1, and Stefan Posse3

1Neurology, University of New Mexico, Albuquerque, NM, United States, 2Neurosurgery, University of New Mexico, Albuquerque, NM, United States, 3Neurology, Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States

We develop a quantitative 3-minute 3D short echo-time (TE) proton-echo-planar-spectroscopic-imaging (PEPSI) protocol. The short scan time is made possible by using partial brain coverage that encompasses the tumor and integration of the water reference (WR) scan into the water suppression module, which enables short repetition time. The method was validated in 5 healthy controls and applied to mapping tumor margins and infiltration in 3 patients with brain tumors. Slab-averaged metabolite/water ratios varied by less than 10% between healthy controls and metabolite concentration values after partial volume and relaxation correction were in the range of our previous study.

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