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Abstract #3864

Assessment of Bound Sodium using Triple Quantum Selection vs. Inversion Recovery at 21.1 T

Nastaren Abad1,2, Ghoncheh Amouzandeh2,3, Jens T. Rosenberg2, Michael G. Harrington4, and Samuel Colles Grant1,2

1Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 2Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, 3Physics, Florida State University, Tallahassee, FL, United States, 4Huntington Medical Research Institutes, Pasadena, CA, United States

This study evaluates Triple Quantum (TQ) and Inversion Recovery (IR) techniques at 21.1 T with regards to bound sodium quantification. Using both gel phantoms imitating physiological concentrations/bound fractions as well as in vivo animal pathological models, the efficiency, SNR and selectivity of 23Na TQ and IR techniques were compared with the ultimate goal of localizing specific sodium changes within intra- and extracellular compartments related to disease progression.

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