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Abstract #3865

Investigating Bound Sodium Signals using a Novel Chemical Shift Imaging Triple Quantum Technique

Nastaren Abad1,2, Ghoncheh Amouzandeh2,3, Jens T. Rosenberg2, Michael G. Harrington4, and Samuel Colles Grant1,2

1Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 2Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, 3Physics, Florida State University, Tallahassee, FL, United States, 4Huntington Medical Research Institutes, Pasadena, CA, United States

23Na-based MRI techniques can be used to separate sodium signal originating from the extracellular and intracellular compartments. Triple Quantum (TQ) schemes can select the coherence pathway that evolves in slow moving/restricted regimes, such as in the intracellular compartment. In this study, a novel TQ technique based on a modified chemical shift imaging sequence (CSI-TQ), which yields higher signal-to-noise ratios, is introduced for studies at 21.1 T. The CSI-TQ is compared to a more conventional gradient recalled echo variant (GRE-TQ) with respect to SNR and efficiency.

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