Abstract #3868

Design of a Dual Saddle Coil Setup for High Resolution 1H/23Na MRI of Ex Vivo Rat Tail Intervertebral Discs at 14.1T

Lance Tyler Williams^1,2, John Edward Clark³, Lukas Neuberger⁴, Gangchea Lee¹, Daniel H. Cortes², and Thomas Neuberger^1,5

¹Biomedical Engineering, The Pennsylvania State University, State College, PA, United States, ²Mechanical and Nuclear Engineering, The Pennsylvania State University, State College, PA, United States, ³Science Dept., Deltona High School, Deltona, FL, United States, ⁴State College High School, State College, PA, United States, ⁵Huck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA, United States

Rat-tail intervertebral disc puncture is a commonly used model for studying treatment options and the pathology of Degenerative Disc Disease (DDD). However, longitudinal studies are impossible as analysis through biochemistry and histology requires euthanization. High-field MRI provides a possible solution to this problem as initial structural and compositional changes related to disc degeneration are observable. In this work, a dual saddle coil was constructed for 1H/23Na imaging at 14.1T. It was concluded from ex vivo rat-tail proton and sodium images that sodium MRI is feasible, and it could be an effective method for rat-tail intervertebral disc degeneration evaluation.

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