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Abstract #3869

Effect of B0 and B1 Field Inhomogeneity Correction on Region-of-Interest Analysis on 3T Sodium 23Na-MRI

Elaine H Lui1, Vijay Venkatraman1, Christopher Steward1, Tie-Qiang Li2, and Patricia M Desmond1

1Department of Medicine and Radiology, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia, 2Department of Medical Radiation and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden

Evaluation of the effect of B0 and B1 correction on region-of-interest (ROI) analysis in forty-one 3T brain 23Na-MRI scans shows average change from B0, B1 and B0B1 correction of 1.0% (p=0.05), -3.7% (p<0.001) and -4.7% (p<0.001) respectively. Effect is more for B1 than B0 correction, and depending on the anticipated effect size of the neurologic disease of interest, B0 +/- B1 correction may not be required, potentially reducing scan time by 66% and thus encourage quantitative 23Na-MRI research in a clinical environment.

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