Abstract #3869

Effect of B0 and B1 Field Inhomogeneity Correction on Region-of-Interest Analysis on 3T Sodium 23Na-MRI

Elaine H Lui¹, Vijay Venkatraman¹, Christopher Steward¹, Tie-Qiang Li², and Patricia M Desmond¹

¹Department of Medicine and Radiology, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia, ²Department of Medical Radiation and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden

Evaluation of the effect of B0 and B1 correction on region-of-interest (ROI) analysis in forty-one 3T brain 23Na-MRI scans shows average change from B0, B1 and B0B1 correction of 1.0% (p=0.05), -3.7% (p<0.001) and -4.7% (p<0.001) respectively. Effect is more for B1 than B0 correction, and depending on the anticipated effect size of the neurologic disease of interest, B0 +/- B1 correction may not be required, potentially reducing scan time by 66% and thus encourage quantitative 23Na-MRI research in a clinical environment.

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