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Abstract #3873

Influence of motion and partial volume effects on measured tissue sodium concentration in cardiac $$$^{23}$$$Na MRI

Johanna Lott1, Jonathan M. Lommen1, Sebastian C. Niesporek1, Tanja Platt1, Nicolas G.R. Behl1, Mark E. Ladd1, and Armin M. Nagel1,2

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Sodium (23Na) ions are involved in many biological processes. The tissue sodium concentration can be determined with 23Na MRI; however, fast relaxation times, breathing and heart motion as well as the high sodium concentration of blood render quantitative determination of the myocardial sodium concentration challenging. We present a method to analyze the tissue sodium concentration within the myocardium by utilizing a partial volume correction as well as correction of motion effects. The presented workflow can reduce the bias by up to 49%.

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