Meeting Banner
Abstract #3878

Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra with different Pulse Sequences at 9.4 T

Theresia Ziegs1,2 and Anke Henning1,3

1High-Field Magnetic Resonance, Max-Planck-Institute of Biological Cybernetics, Tübingen, Germany, 2Graduate School of Neural and Behavioural Sciences, Tuebingen, Germany, 3Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate in pure 1H MRS spectra without a 13C channel. In this work, simulated 1H MRS spectra with FID, semi-Laser, and two PRESS sequences have been compared to optimize spectral resolution for glutamate and glutamine measurements at 9.4 T. Furthermore, spectral changes according to a two-compartment model were analyzed. As a result, this work indicates the fastest possible acquisition can be obtained with an FID sequence, while the best resolution possible can be obtained with a PRESS sequence.

This abstract and the presentation materials are available to members only; a login is required.

Join Here